A trusted chair of PyCon US 2011, Van Lindberg, did a post explaining some of the behind-the-scenes issues that must be worked out when organizing the conference. It's an interesting post that's worth reading.
But one of the key take-aways from that post is that the hotel space is going quickly. We have already taken 105% of our allotted space. It's already projected that we will sell out PyCon this year. Make sure you register if you have not already else you may very well find yourself unable to attend no matter how badly you want to come.